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瓦赫宁根大学和 Nutriad 展示丁酸盐研究方面取得的成果
发布时间:2018-08-02    

 

Feed additive producer Nutriad, a pioneer in sodium butyrate applications for the animal feed industry, co-financed a research project on the use of butyrate as feed additive. The multi-year research project was concluded with the Ph.D. thesis of Pierre Moquet on the effects of butyrate in broiler diets, which he successfully defended on June 22nd at Wageningen University (Netherlands).

饲料添加剂生产商 Nutriad 是动物饲料行业丁酸钠应用的先驱,合作资助了一项关于使用丁酸盐作为饲料添加剂的研究项目。Pierre Moquet博士论文就肉鸡日粮中丁酸盐的影响对多年研究项目进行了总结,于 6 22 日在荷兰瓦赫宁根大学进行了成功答辩。

Dr. Moquet started his Ph.D.-research in the Wageningen Animal Nutrition Group (WUR) to investigate an important conundrum related to the use of butyrate as an additive in animal feed: on one hand, this molecule has received considerable attention for its potential to improve intestinal health and animal performance, while on the other hand, the mechanisms underlying these effects have been described as very diverse and seemingly less consistent.

Moquet 博士在瓦赫宁根动物营养组织 (WUR) 开始他的博士研究,研究了丁酸盐作为动物饲料添加剂使用的一个重要难题:一方面,这种分子在改善肠道健康和动物表现方面的潜力受到了相当多的关注,另一方面,这些影响背后的机制非常多样化,并且貌似不太一致。

Together with a fellow Ph.D. student at Ghent University, Dr. Moquet set out to explore this topic in the framework of a research project that was co-financed by feed additive producer Nutriad and VLAIO, the Flanders Innovation & Entrepreneurship agency. Dr. Tim Goossens, Business Development Manager Digestive Performance at Nutriad, coordinated support for the project.

与根特大学的博士生一起,Moquet 博士在饲料添加剂生产商 Nutriad 纽蔼迪和法兰德斯创新机构 VLAIO 共同资助该主题项目研究。Nutriad 的消化性能业务开发经理 Tim Goossens 博士负责协调对该项目的支持。

Dr. Goossens explained: “Dr. Moquet found evidence supporting his hypothesis that at least part of this variation can be attributed to the fact that different products deliver butyrate in distinct parts of the gastrointestinal tract (GIT). These different release profiles result in specific digestive, microbial and immunological responses.”

Goossens 博士解释说:“Moquet 博士发现证据支持他的假设,至少部分这种变化可以归因于这样一个事实,即不同的产品在胃肠道 (GIT) 的不同部位输送丁酸盐。这些不同的释放曲线导致特定的消化、微生物和免疫反应。”

For example, when butyrate levels were increased solely in the proximal part of the GIT, or specifically in the small intestine, expression of host defense peptides was modulated and the levels of certain antibodies in the blood was increased. However, these treatments also triggered caecal microbial dysbiosis and inflammatory responses. On the contrary, when additives where used to increase butyrate not only in the proximal GIT, but also the hindgut, no signs of gut inflammation were observed, while the apparent digestibility of methionine was improved, as well as the feed conversion ratio.

例如,当丁酸水平单独添加在 GIT 的近端部位或特别在小肠中增加时,宿主防御肽的表达会被调节并且血液中某些抗体的水平增加。可是这些处理也引发了盲肠微生态失调和炎症反应。相反,当使用添加剂不仅在近端 GIT,而且还在后肠增加丁酸盐时,没有观察到肠道炎症的迹象,而蛋氨酸的表观消化率提高,饲料转化率也提高。

 “All in all, the data suggest that butyrate indeed has the potential to elicit important gut health stimulating mechanisms”, Dr. Goossens concluded, “but it is not an ‘always beneficial, everywhere’ product. Instead, the importance of precision delivery of this molecule is highlighted once more. This is especially important for butyrate producers if they are to provide practical and smart solutions to animal producers”.

“最重要的是,数据表明了丁酸确实具有引发重要的肠道健康促进机制的潜在能力。”Goossens 博士总结道,“但丁酸产品并非在任何位点都可以带来收益”。因此,将这种分子进行精确输送的重要性再次凸显出来。如果丁酸型生产者要为动物生产者提供实用和智能的解决方案,这一点尤其重要”。

Nutriad delivers products and services to over 80 countries, supported by 4 application laboratories and 5 manufacturing facilities on 3 continents. Find out more at www.nutriad.com

Nutriad 向全球 80 多个国家/地区提供产品和服务,由位于三大洲的四个应用实验室和五个制造工厂提供大力支持。访问 www.nutriad.com 了解更多信息


 
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